Los Cuates Middle School is located on Texas Highway 100 in the cluster of the district’s three oldest campuses. The building served as the Los Fresnos High School campus until 1992.
Los Cuates, which opened in 1962 as LFHS, is located next to Leo Aguilar Memorial Stadium and the Los Fresnos CISD Aquatic Center. Additions were made to the school in 1965, 1968, 1974, 1975, 1986 and 1992. The school began serving middle school students in 1993.
LCMS houses about 830 students in grades 6 to 8. Dora Romero, Lopez-Riggins and Palmer-Laakso elementary schools served as feeder schools to LCMS. The school mascot is Cougars and the principal is Antonio Padilla Jr.